Formation of long-term memory without short-term memory revealed by CaMKII inhibition
Nature Neuroscience volume 28, pages 35–39 (2025 )Cite this article
Long-term memory (LTM) consolidation is thought to require the prior establishment of short-term memory (STM). Here we show that optogenetic or genetic CaMKII inhibition impairs STM for an inhibitory avoidance task at 1 h but not LTM at 1 day in mice. Similarly, cortico-amygdala synaptic potentiation was more sensitive to CaMKII inhibition at 1 h than at 1 day after training. Thus, LTM does not require the formation of STM, and CaMKII-dependent plasticity specifically regulates STM for avoidance memory.
The code used for data acquisition and analysis in our electrophysiological experiments is available at https://github.com/ryoheiyasuda/FLIMage_Matlab_phys.git.
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