New York, June 16 :  Researchers have identified several human antibodies that target SARS-CoV-2, the virus responsible for Covid-19, according to thr

Neutralizing antibodies against Covid-19 virus identified

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2020-06-16 18:53:01

New York, June 16 : Researchers have identified several human antibodies that target SARS-CoV-2, the virus responsible for Covid-19, according to three papers published in the journal Science.

Several of these antibodies showed protective, neutralizing capabilities, offering promising therapeutic leads, and eight antibodies from one analysis were discovered to cross-react with a related bat-specific coronavirus.

The findings have implications for the identification of broadly neutralizing antibodies to protect against potential new coronavirus outbreaks in the future.

In one study, Philip Brouwer from University of Amsterdam and colleagues isolated 403 monoclonal antibodies from three convalescent Covid-19 patients, showing that the patients had strong immune responses against the viral spike, a protein complex that binds to the ACE2 receptor to facilitate entry into human host cells.

A subset of these antibodies neutralized the virus by targeting diverse epitopes on the spike, with the two most potent ones targeting the domain that binds the host receptor.

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