Early adult binge drinking has lasting impact on aging brain in mice | Penn State University
New research shows that binge drinking in early adult mice can lead to long-lasting and potentially permanent dysregulation in the brain. The researchers used patch-clamp electrophysiology, shown here, to understand how signaling in the brain was impacted by alcohol after a long period of abstinence. Credit: Kelby Hochreither / Penn State. Creative Commons
UNIVERSITY PARK, Pa. — Binge drinking in early adults can lead to long-lasting and potentially permanent dysregulation in the brain, according to a new study in mice, led by researchers at Penn State. They found that neurons, cells that transmit information in the brain via electrical and chemical signals, showed changes following binge drinking were similar in many ways to those seen with cognitive decline.
These findings, published in the journal Neurobiology of Aging, reveal that binge drinking early in life may have lasting impacts that are predictive of future health issues, like Alzheimer’s disease and related dementias, the researchers said. The work could inform the development of therapeutics to help combat these changes — particularly in aging populations who may have given up alcohol decades earlier, according to Nikki Crowley, director of the Penn State Neuroscience Institute at University Park, Huck Early Career Chair in Neurobiology and Neural Engineering, assistant professor of biology in the Eberly College of Science, and the leader of the research team.
