nanodjango. Richard Terry demonstrated this in a lightning talk at DjangoCon US today. It's the latest in a long line of attempts to get Django to work with a single file (I had a go at this problem 15 years ago with djng) but this one is really compelling.
That's it! This gave me a fully configured Django application with models, migrations, the Django Admin configured and a bunch of other goodies such as Django Ninja for API endpoints.