Neuroscience is at a crossroads. The latest advances in electrophysiology and optophysiology, such as Neuropixels probes and light-sheet microscopy, h

To keep or not to keep: Neurophysiology’s data dilemma

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2024-12-01 01:30:04

Neuroscience is at a crossroads. The latest advances in electrophysiology and optophysiology, such as Neuropixels probes and light-sheet microscopy, have pushed the boundaries of what we can record from the brain. These technologies are generating vast amounts of data—single experiments can produce petabytes’ worth—far more than we have ever dealt with before, sparking a critical discussion: How do we store and access all this information? Should we be keeping all raw data or focusing on processed datasets? And if we can’t keep everything, how do we decide what to discard?

Raw data are the most complete and unfiltered record of an experiment, capturing every detail, including those that might seem irrelevant at first. It is indispensable for certain types of research, particularly when it comes to developing new methodologies or uncovering novel insights. Refined spike-sorting algorithms, for example, might extract meaningful patterns from what currently appears to be background activity.

Both processed and raw data have their unique advantages and challenges. Understanding the trade-offs between the two is crucial for determining what to keep and how to make the most of the data we generate.

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