Python 3 has optional type hints (and has had them for some time), and some time ago I was a bit tempted to start using some of them; more recently, I wrote a small amount of code using them. Recently I needed to write a little Python program and as I started, I was briefly tempted to try type hints. Then I decided not to, and I suspect that this is how it's going to go in the future.
The practical problem of type hints for me when writing the kind of (small) Python programs that I do today is that they necessarily force me to think about the types involved. Well, that's wrong, or at least incomplete; in practice, they force me to come up with types. When I'm putting together a small program, generally I'm not building any actual data structures, records, or the like (things that have a natural type); instead I'm passing around dictionaries and lists and sets and other basic Python types, and I'm revising how I use them as I write more of the program and evolve it. Adding type hints requires me to navigate assigning concrete types to all of those things, and then updating them if I change my mind as I come to a better understanding of the problem and how I want to approach it.
(In writing this it occurs to me that I do often know that I have distinct types (for example, for what functions return) and I shouldn't mix them, but I don't want to specify their concrete shape as dicts, tuples, or whatever. In looking through the typing documentation and trying some things, it doesn't seem like there's an obvious way to do this. Type aliases are explicitly equivalent to their underlying thing, so I can't create a bunch of different names for eg typing.Any and then expect type checkers to complain if I mix them.)