COVID-19 vaccines are effective and induce a strong immune response. Cure-Hub's own data shows high neutralizing antibody levels after vaccinatio

COVID-19 Natural Immunity vs Vaccine Immunity

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2021-06-15 02:30:04

COVID-19 vaccines are effective and induce a strong immune response. Cure-Hub's own data shows high neutralizing antibody levels after vaccination, especially after the second mRNA dose. In fact, two doses of the Pfizer and Moderna vaccines can push antibody production higher than natural infection (Vaccines vs Natural Infection | Cure-Hub).

However, this does not mean vaccine induced immunity is superior to natural immunity. Below we provide evidence that recovery from natural infection generates a more diverse immune response.

There are 5 proteins encoded in the viral genome: Nucleocapsid (N), Spike (S), Hemagglutinin esterase (He), Membrane (M) and Envelope (E).

The most important protein is S, which the virus uses to enter human cells. By blocking S, SARS-CoV-2 cannot bind to the human ACE2 receptor and cannot cause an infection.

Due to S protein's critical role in COVID-19 infection, it is the target for Pfizer, Moderna and J&J COVID-19 vaccines. Specifically, those vaccines are designed against the S protein receptor binding domain (RBD), which is the part that interacts with human ACE2.

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