Upper Gastrointestinal Mucosal Damage and Subsequent Risk of Parkinson Disease
Other race and ethnicity included Asian and Black individuals as well as those with racial identifications that did not fit into those categories. CCI indicates Charlson-Deyo Comorbidity Index; GERD, gastroesophageal reflux disease; H pylori, Helicobacter pylori; HR, hazard ratio; NSAID, nonsteroidal anti-inflammatory drug; OR, odds ratio; PPI, proton-pump inhibitor.
Chang JJ, Kulkarni S, Pasricha TS. Upper Gastrointestinal Mucosal Damage and Subsequent Risk of Parkinson Disease. JAMA Netw Open. 2024;7(9):e2431949. doi:10.1001/jamanetworkopen.2024.31949
Question Is upper gastrointestinal mucosal damage associated with increased risk of subsequent Parkinson disease (PD) diagnosis?
Findings In this cohort study of 9350 patients with no prior history of PD, findings of mucosal damage on upper endoscopy were associated with a 76% greater risk of developing a clinical PD diagnosis.
Meaning These findings suggest that increased vigilance among patients with upper gastrointestinal mucosal damage for future PD risk may be warranted.
