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Scientists learn from caterpillars how to create self-assembling capsules for drug delivery

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2024-05-01 01:30:04

This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

Self-assembling molecules that spontaneously organize themselves to form complex structures are common in nature. For example, the tough outer layer of insects, called the cuticle, is rich in proteins that can self-assemble.

Self-assembly is a cost-effective, environmentally sustainable and quick way of manufacturing nanostructures with critical applications in various industries, ranging from therapeutics to self-replicating machines.

Harnessing the self-assembling abilities of proteins from the cuticles of Asian corn borer moth caterpillars (Ostrinia furnacalis), Nanyang Technological University, Singapore (NTU Singapore) scientists have created nanosized capsules that could be used to deliver drugs and messenger RNA (mRNA). mRNA is a molecule that instructs cells to produce proteins and has been used in COVID-19 vaccines.

Found in regions from China to Australia, the Asian corn borer moth is an agricultural pest that destroys corn crops, with the caterpillars causing the damage. The cuticle of the head of the caterpillar protects it and gives it unique mechanical properties.