Lab tests show novel bone cancer therapy has 99% success rate

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2024-09-19 16:30:04

Bioactive glasses, a filling material which can bond to tissue and improve the strength of bones and teeth, has been combined with gallium to create a potential treatment for bone cancer.

Tests in labs have found that bioactive glasses doped with the metal have a 99 percent success rate of eliminating cancerous cells and can even regenerate diseased bones.

The research was conducted by a team of Aston University scientists led by Professor Richard Martin. Professor Martin is also partnered with the Royal Orthopaedic Hospital in Birmingham, a leader in orthopaedic oncology specialising in the diagnosis, treatment and research of benign and malignant tumours of bone and soft tissues.

In laboratory tests 99% of osteosarcoma (bone cancer) cells were killed off without destroying non-cancerous normal human bone cells. The researchers also incubated the bioactive glasses in a simulated body fluid and after seven days they detected the early stages of bone formation.

Gallium is highly toxic, and the researchers found that the ‘greedy’ cancer cells soak it up and self-kill, which prevented the healthy cells from being affected. Their research paper Multifunctional Gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcoma has been published in the journal Biomedical Materials.