The Worst Argument Against Ozempic - Cremieux Recueil
GLP-1 receptor agonists (henceforth, GLP-1s) are proving to be miracle drugs, but as with any miracle, they have their doubters. The doubters have developed many arguments against GLP-1s and the arguments vary in sophistication, but they thus far fail to overturn the GLP-1 value proposition. I want to briefly mention what I consider to be the worst argument against GLP-1s, because it is an argument that is both popular and weak.
The arguments that GLP-1s are bad because of a litany of side effects that lack strong empirical support, because they have side effects that are indistinguishable from the effects of weight loss more generally, or because they cause transient delayed gastric emptying (gastroparesis) are among the most common, and they’re unimpressive, but neither is the argument that I consider to be the worst.
A… drawback, however, is that those who start taking [GLP-1s] are likely to depend on them for life. Stop, and the weight piles back on, just as with most conventional diets. In the first year after stopping a 2.4mg dose of semaglutide, people regain two-thirds of the weight they lost. And, as with dieting, some people even put on more weight than they started with.
