Huimin Chen, Jiaxin Liu, Gege Tang, Gefei Hao, Guangfu Yang, Bioinformatic Resources for Exploring Human-virus Protein-protein Interactions Based on

Bioinformatic Resources for Exploring Human-virus Protein-protein Interactions Based on Binding Modes

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2024-10-19 23:30:04

Huimin Chen, Jiaxin Liu, Gege Tang, Gefei Hao, Guangfu Yang, Bioinformatic Resources for Exploring Human-virus Protein-protein Interactions Based on Binding Modes, Genomics, Proteomics & Bioinformatics, 2024;, qzae075, https://doi.org/10.1093/gpbjnl/qzae075

Historically, there have been many outbreaks of viral diseases that have continued to claim millions of lives. Research on human-virus protein-protein interactions (PPIs) is vital to understanding the principles of human-virus relationships, providing an essential foundation for developing virus control strategies to combat diseases. The rapidly accumulating data on human-virus PPIs offer unprecedented opportunities for bioinformatics research around human-virus PPIs. However, available detailed analyses and summaries to help use these resources systematically and efficiently are lacking. Here, we comprehensively review the bioinformatic tools used in human-virus PPIs research, discuss and compare the function, performance, and limitations of these web resources. This study aims to provide researchers with a bioinformatic toolbox that will hopefully better facilitate the exploration of human-virus PPIs based on binding modes.

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